The STEP 1 trial reported an average weight loss of 3.8% after 4 weeks with the 2.4 mg dose of semaglutide. On average, people can expect to lose 5 to 10% of their body weight over several months while taking semaglutide. For example, a small study found that participants with a BMI of 27 or more lost an average of 14 pounds after three months of weekly injections. This breaks down to approximately 4-5 pounds per month. Between weeks 4 and 8, many people lose 5 to 10 pounds.
Suppressing your appetite continues to help control your calorie intake, and you may begin to notice consistent weight loss. Consistency with a healthy diet and regular physical activity is essential during this stage. Research has shown that 2.4 mg of semaglutide can cause a weight loss of around 16% of body weight, or between 16 and 17 kg, after 68 weeks. Semaglutide is a prescription medication that helps control hunger and food intake, making it easier to lose weight.
Weight loss processes are rarely linear, and finding a sustainable and effective solution is often a challenge. Rest assured that while the first week's results are modest, you can expect weight loss to increase with sustained use of semaglutide over the coming weeks and months. GLP-1 is a goal for weight control, as it delays gastric emptying and promotes satiety, reducing food intake. These lower levels of hunger (or decreased appetite) will mean you'll eat fewer calories and lose weight over time.
It's crucial that people considering using semaglutide for weight loss work closely with their healthcare provider to determine the appropriate treatment plan, including duration and dosage. The elimination half-life of semaglutide is approximately 1 week; therefore, semaglutide will be present for approximately 5 to 7 weeks after the last dose. People who took semaglutide and made healthy lifestyle changes lost an average of 15.2% of their body weight at 104 weeks, or two years. The emphasis remains on combining semaglutide with lifestyle changes, such as a balanced diet and regular exercise, for optimal results.
In the two above-mentioned trials, the average weight loss of 0.5 mg between weeks four and eight was approximately 2%. For 68 weeks, patients treated with semaglutide lost an average of 15.8% of their body weight, compared to 6.4% they lost with liraglutide (e.g. by attacking GLP-1 receptors in the brain, semaglutide helps to feel satisfied sooner and reduces cravings).
